Tirzepatida is a remedy indicated for the treatment of type 2 diabetes mellitus in adults as it helps increase the production of insulin by the pancreas and reduce the amount of glucose produced by the liver, which allows to lower blood sugar levels.
This medicine is found in the form of injection for weekly application, with the commercial name Mounjaro, and can be used alone or in conjunction with other antidiabetic remedies, and associated with a balanced diet and exercise.
Also read: MOUNJARO: What is it for, how to use and side effects
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Tirzepatida should be used with indication of the endocrinologist and regular medical follow -up, to evaluate the effectiveness of treatment and the emergence of side effects.
So that Serve
Tirzepatida is indicated for the treatment of uncontrolled type 2 diabetes mellitus, and should be part of a balanced diet and exercise to control blood sugar levels.
This remedy can be used alone when the person has intolerance or contraindications to treatment with metformin or used in conjunction with other antidiabetic remedies, according to the orientation of the endocrinologist. Check out the main drugs for diabetes.
How it works
Tirzepatida has a double action as it acts on GLP-1 receptors (peptide-1 similar to glucagon) and GIP receptors (insulinotropic polypeptide dependent on glucose) present in the pancreas, brain, intestines, hearts, adipose tissue, leukocytes and blood vessels.
GLP-1 and GIP are hormones, called incredetins, naturally produced by the intestine, and which have the function of stimulating insulin release by pancreatic cells, reducing the amount of glucose produced by the liver, decreasing gastric emptying and promoting satiety.
In this way, this remedy helps to regulate blood sugar levels, reduce glucagon levels, improve insulin sensitivity, reduce hunger for food intake, and modulate fat metabolism.
Fits to lose weight?
Tirzepatida has shown a weight reduction in people with type 2 diabetes, as it sends signs of satiety to the brain and reduces gastric emptying, reducing hunger, causing a reduction in the amount of calories ingested daily and, therefore, this medicine can also lead to weight loss.
Some studies [1,2] They have shown that tirzepatida has a greater effect on weight reduction than semaglutado in people with obesity or overweight, as in addition to activating GLP-1 receptors, it also stimulates GIP receptors.
However, this remedy has no official indication and approved by Anvisa to lose weight, in cases of obesity or overweight, and does not replace regular physical activity and the balanced weight loss diet. Learn how to do a balanced diet to lose weight.
In addition, there is another remedy that contains tirzepatida, Zepbound, which is suitable for weight loss, but is not yet available in Brazil.
Also read: Pen to lose weight: what they are, how they work (and which one is best)
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Tirzepatida Need Revenue?
Tirzepatida needs revenue to be bought in pharmacies and drugstores.
To buy the tirzepatida, it was determined by Anvisa, which will need two routes of the recipe, and a road will be retained in the pharmacy.
The validity time of the revenue of the Tirzepatitado will be 90 days from the date of the prescription signed by the doctor.
How to use
Tirzepatit should be used through injections applied to the subcutaneous layer of the skin (under the skin) of the belly, thigh or upper arm, and can be applied before or after a meal at any time of the day. See how to apply injection under the skin correctly.
The normally recommended doses of adult tirzepatida are:
- Initial dose: 1 application of 2.5 mg of thyzepatida, once a week. After 4 weeks, the dose may be increased by the doctor to 5 mg, once a week;
- Maintenance dose: 5 mg, 10 mg or 15 mg of tirzepatida, once a week, according to medical advice.
The increase in the doses of tirzepatida should be done with orientation of the endocrinologist, with increments of 2.5 mg, after at least 4 weeks with the same dose, according to the response to treatment, tolerance to this remedy and the emergence of side effects.
The maximum dose of thypatide should not exceed 15 mg per week.
Tirzepatida is found in the form of a filled injectable pen, with doses of 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg and 15 mg, and the application site is recommended to vary each week.
What to do in case of oblivion
If you forget to apply the weekly dose on the right day and time, you can apply it immediately up to a maximum of 4 days of oblivion.
After 4 days of oblivion, you should skip the forgotten dose and continue the weekly scheme as programmed.
2 doses should not be applied, with a 3 -day interval between one and another dose.
Possible side effects
The most common side effects of thypatide are nausea, vomiting, diarrhea, abdominal or stomach pain, excess intestinal gases, frequent belts, gastroesophageal reflux, constipation, swollen belly or fatigue.
In addition, tirzepatida can greatly reduce blood sugar and cause hypoglycemia, especially when used with other diabetes remedies. Learn to identify the symptoms of hypoglycemia.
Tirzepatida can also cause side effects at the injection site, such as pain, itching, irritation, injury and purple spots near the place where it was applied.
Although rare, tirzepatide can cause severe allergic reactions, and it should be interrupted and seeking the emergency room immediately if symptoms appear such as difficulty to breathe, chest pain, closed throat, swelling in the mouth, tongue or face, or hives.
Immediate medical care should be sought if symptoms of pancreatitis, such as pain in the upper abdomen that can radiate to the back or white or white feces with signs of fat, for example. See all symptoms of pancreatitis.
Who should not use
Tirzepatida should not be used by children and adolescents or people who have type 1 diabetes, pancreatitis or allergy to this medicine or any other component of the formula.
In addition, this remedy should be used with caution in people with serious gastrointestinal diseases such as gastroparesis, or have diabetic retinopathy, or elderly people over 85 years old.
During pregnancy or breastfeeding, tirzepatito should only be used if recommended by the doctor after evaluating the benefits of treatment for women and potential risks to the baby.
Source: www.tuasaude.com