The COVID-19 BNT162B2 vaccine Developed by the Pfizer pharmacist could provide more benefits of those expected, since a team of researchers from Trinity College has discovered that this vaccine, in addition to protecting against the coronavirus Sars-COV-2, also seems to decrease and control the innate inflammation that is triggered because of infections caused by bacterial and fungal pathogens not directly related to this virus.
Innate immunity constitutes the first defensive barrier of our body. There is a phenomenon known as “trained immunity”, which refers to the ability of this immune response to “remember” previous exhibitions and react more effectively to future infections.
During the pandemic, the Vaccines based on DNA mesajer technologyOr, such as the BNT162B2, they represented an important advance, demonstrating great efficacy against severe COVID-19 and significantly reducing associated mortality. Although it was well known how these vaccines stimulated the production of antibodies and adaptive immune memory, its impact on the innate immune system remained unclear so far.
Implications of the study for the design of future vaccines
The Trinity team carried out its study with eight healthy volunteers, who were removed blood before receiving the vaccine and then 14 and 28 days after the first dose. The analyzes revealed that after vaccination the production of inflammatory mediators against bacterial, fungal and viral infections decreased, compared to the levels prior to the vaccine.
In addition, a proteomic analysis showed a reduction of inflammatory markers after vaccination. These findings have been published in the magazine Clinical Immunology And they indicate that the vaccine could modulate the innate immune response, reducing inflammation in a similar way to the phenomenon of transflammatory immunity with an anti -inflammatory effect.
Randomized clinical studies have shown that there are important differences between vaccine platforms in terms of non -specific effects, and the results of the Trinity study could help explain the differences observed between vaccines based on messenger RNA and those of adenoviraral vectors in terms of their impact beyond its main objective.
“This study has improved our understanding of the non -specific effects on innate immunity of RNM vaccines, which will help guide pandemics preparation.”
“The findings of our study highlight the importance of exploring innate immune responses to vaccination after initial preparation. This work establishes that HRNM vaccination can alter innate immune responses to related and unrelated pathogens. This is transcendental because it will provide information on the broader immunological effects of vaccination and how these can be used to optimize the design and programming Vaccines, “said Sarah Connolly, a doctoral student at the Basdeo Laboratory, of the St James Hospital, who carried out this research, with financing of Research Ireland, in a note published by Trinity College.
“Since the Arnm Vaccine Platform is new and very successful, this study has improved our understanding of its non -specific effects on innate immunity, which will help guide the preparation against pandemics and the ability of this platform to protect against other infectious diseases or regulate inflammation,” adds Dr. Sharee Basde Trinity translational medicine of the St James hospital and main author.
The authors of the study underline that, although the ability to reduce inflammation can be beneficial in contexts such as severe COVID-19 or in immunomedized diseases, it is important to consider the context in which these effects occur.
Likewise, the study opens new perspectives on how to design vaccines in the future. Until now, the development of vaccines has focused mainly on activating adaptive immunity, but better understanding the impact on the innate response and trained immunity could allow the creation of immunizations that not only protect against specific threats, but also generally strengthen the organism’s defenses against multiple infections.
Source: www.webconsultas.com